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c-KIT phosphorylation directly activates p38 mitogen-activated protein kinase (MAPK), a member of the MAP kinase family, which in turn phosphorylates CREB and subsequently activates MITF to promote TYR transcription (34)

Essentially, methylmercury is thought to disrupt some of the cell signaling taking place when neurons are forming.[ref] The term Mad as a hatter referred to the neurological changes from long-term mercury exposure